Tierra has been perfecting the science of cell-free systems, starting from technology originally developed at Caltech and backed by DARPA. We deploy automation and AI, our learning platform, around proprietary cell-free systems to enable combinatoric protein synthesis that is completely ex vivo. Three things can be easily varied using Tierra technology that is difficult when using cells:
Different DNA variants of the input can be produced and expressed in parallel.
Tierra has multiple cell-free systems representing the diversity of life, spanning gram-positive, gram-negative, and eukaryotic species.
Known additives to the system, such as cofactors or salts, can be supplemented.
The end product is not only physical protein, but also multiple layers of rich and actionable data that informs the protein synthesis workflow.